perc

Active Projects

There are currently 18 ongoing projects that are recruiting patients/participants at 2 or more PERC sites. The majority of these studies have been successful at obtaining grant funding (83%).


Current Projects

Title: Understanding Discharge Instruction for Children and Caregivers in the Transition from Pediatric Emergency Care


Principal Investigator: Janet Curran
Study Design: qualitative, retrospective chart review, focus groups
Funding Agency: Joint funding from Nova Scotia Health Research Foundation and CIHR Funding
Amount: $435,804
Project Summary & Impact:

Title: Short-Course Antimicrobial Therapy for Paediatric Respiratory Infections (SAFER)


Principal Investigator: Jeffrey Pernica
Study Design: RCT
Funding Agency: Physician Services Incorporated
Funding Amount: $169,500
Project Summary & Impact:

Title: Safety Surveillance: Adverse Events in Procedural Sedation


Principal Investigator: Maala Bhatt
Study Design: Database Surveillance System
Funding Agency: CIHR Team Grant
Funding Amount: $202,885
Project Summary & Impact:

Title: Pharmacotherapy Practice Patterns and Outcomes in Bronchiolitis in the Americas, Australia/New Zealand and Europe


Principal Investigator: Suzanne Schuh
Study Design: Prospective Cohort
Funding Agency: None
Funding Amount: NA
Project Summary & Impact:

Title: Persistent Postconcussive Symptoms in Children: A Clinical Prediction Rule Derivation Study


Principal Investigator: Roger Zemek
Study Design: Prospective Cohort
Funding Agency: CIHR
Funding Amount: $1,114,530
Project Summary & Impact:

Title: Pathogen specific effectiveness of probiotics in children with acute gastroenteritis


Principal Investigator: Stephen Freedman
Study Design: Prospective Cohort
Funding Agency: CIHR
Funding Amount: $607,891
Project Summary & Impact:

Title: Long-term effects of corticosteroids in term infants


Principal Investigator: David Johnson
Study Design: RCT
Funding Agency: The Lung Association
Funding Amount: $29,981
Project Summary & Impact:

Title: How safe are our pediatric emergency departments? A national prospective cohort study


Principal Investigator: Amy Plint
Study Design: Prospective Cohort
Funding Agency: CIHR
Funding Amount: $1,129,365
Project Summary & Impact:

Title: Herpes Simplex Virus (HSV) Infection in Young Infants


Principal Investigator: Dina Kulik
Study Design: Retrospective Cohort
Funding Agency: None
Funding Amount: NA
Project Summary & Impact:

Title: Exploring Novel Methods to Improve our Diagnostic Accuracy of Childhood Bacterial Pneumonia


Principal Investigator: David Johnson
Study Design: Prospective Cohort
Funding Agency: CIHR Team Grant
Funding Amount: $198,949
Project Summary & Impact:

Title: Epidemiology, Risk Factors, and Characterization of Infant Visits to an Emergency Department in the First 28 Days After Birth for the Province of Ontario - survey


Principal Investigator: JoAnn Harrold
Study Design: Survey
Funding Agency: CHAMO Innovation
Funding Amount: $89,912
Project Summary & Impact:

Title: Avoiding and Treating Children's Pain and Anxiety in Canadian Pediatric Emergency Departments: A Pediatric Emergency Research Canada Survey


Principal Investigator: Evelyne Trottier
Study Design: Survey of physician at each PERC site
Funding Agency: None
Funding Amount: NA
Project Summary & Impact:

Title: Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE): Epidemiology, Emerging Organisms, and Economics


Principal Investigator: Stephen Freedman
Study Design: epidemiologic and economic analysis
Funding Agency: Alberta Innovates Health Services
Funding Amount: $4,999,164
Project Summary & Impact:

Title: A Trial to Determine Whether Septic Shock Reversal is Quicker in Pediatric Patients Randomized to an Early Goal Directed Fluid-Sparing Strategy vs. Usual Care (SQUEEZE Trial)


Principal Investigator: Melissa Parker
Study Design: RCT
Funding Agency: CIHR
Funding Amount: $300,000
Project Summary & Impact:

Title: A Knowledge Translation 'Laboratory': The Development and Implementation of Clinical Pathways for Two Common Childhood Emergencies


Principal Investigator: David Johnson
Study Design: Pathway implementation
Funding Agency: CIHR Team Grant
Funding Amount: $321,440
Project Summary & Impact:

Magnesium Nebulization Utilization in Management of Pediatric Asthma


Principal Investigator: Suzanne Schuh
Study Design: RCT
Funding Agency: CIHR
Funding Amount: $2,137,058

Project Summary:

Primary aims and objectives:   To examine the utilization of intravenous magnesium in Canadian pediatric Emergency Departments (EDs) in children requiring hospitalization for acute asthma and association of administration of frequent albuterol/ipratropium and timely corticosteroids with hospitalization.

Primary outcomes Hospitalization for persistent/recurrent respiratory distress within 24 hours of starting the experimental treatment, defined as a decision of the treating ED physician to admit the child to an inpatient unit.

Secondary outcomes Changes in the PRAM, respiratory rate and oxygen saturation from the start of the first experimental nebulization to 60, 120, 180 and 240 minutes and the changes in the blood pressure from the first experimental nebulization to 20, 40, 60, 120, 180 and 240 minutes.

Impact of Emergency Department Probiotic Treatment of Pediatric Gastroenteritis


Principal Investigator: Stephen Freedman
Study Design: RCT
Funding Agency: CIHR
Funding Amount: $2,231,298

Project Summary: PROGUT is a randomized, placebo-controlled, double-blind, five-center, Canadian, emergency department trial. Children aged 3 months to 48 months who present between November 2013 and June 2017 with <72 hours of gastroenteritis symptoms will be assessed for eligibility. A total of 886 children will be randomized (1:1 allocation via an internet based, third party, randomization service) to receive 5 days of a combination probiotic agent (Lactobacillus rhamnosus and L. helveticus) or placebo.

Primary outcomes Development of moderate to severe disease in the 2 weeks after the index visit [Time Frame: Measured daily for 14 days]

Secondary outcomes Duration of Diarrhea [Time Frame: Daily for 14 days] Duration of Vomiting [Time Frame: Daily for 14 days] Return visits for unscheduled care to a health care provider related to vomiting, diarrhea, dehydration, fever, or fluid refusal, within two weeks [Time Frame: Daily for 14 days] Work and Daycare Absenteeism [Time Frame: Daily for 14 days]

Developing an Internet-based Program for Anxious Youth who visit the Emergency Department for Mental Health Care: A Strategy to Increase Access to Care


Principal Investigator: Mandi Newton
Study Design: Development and Usability testing of Internet-based CBT
Funding Agency: CIHR & RBC Foundation
Funding Amount: $831,715

Project Summary: Anxiety disorders can have serious negative effects on a young person's personal relationships, school performance, and family life. These disorders may not be discovered by youth, parents, and health care providers. Even if anxiety disorders are discovered, youth may not get the right therapy. Anxious youth can become sick if their anxiety is not treated properly. Many youth go to a hospital emergency department when they are sick, for help with their anxiety. This is called a crisis. In Alberta, we studied these crisis visits and found that most anxious youth receive counselling and referral for follow-up care. However, the wait time can be 29 to 40 days before youth see a doctor for follow-up care. During this wait, many youth need to return to the emergency department for more crisis care. We see a need to create a treatment so that anxious youth do not have to wait for care. This treatment would help them after an emergency department visit. Our team will carry out research to produce and test Wired!, our new Internet-based treatment for youth with anxiety problems. Youth can use this treatment from home after their emergency department visit. Wired! materials will be created and tested by our research team, with frequent input from youth and mental health professionals. Wired! will include information materials and personalized homework assignments to help anxious youth learn ways to manage anxiety. Youth could also talk to a professional therapist through an online discussion board. Our testing of Wired! will start with a pilot study with real patients. In the future, we plan full-scale scientific testing for the safety and usefulness of Wired!.

Primary aims and objectives:   This pilot trial aims to collect the necessary data to inform the planning of a full-scale RCT to test the effectiveness of the Internet-based CBT program Breathe (Being Real, Easing Anxiety: Tools Helping Electronically).








  Visit the link below to view synopsis


  Visit the link below to view synopsis


  Visit the link below to view synopsis



Alberta Children's Hospital
Cubicle: C4-636-07
2888 Shaganappi Trail NW
Calgary,  Alberta , Canada
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